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Gmeiner, William
One or more keywords matched the following items that are connected to
Gmeiner, William
Item Type
Name
Academic Article
Targeted drug delivery to chemoresistant cells: folic acid derivatization of FdUMP[10] enhances cytotoxicity toward 5-FU-resistant human colorectal tumor cells.
Academic Article
Efficacy and safety of FdUMP[10] in treatment of HT-29 human colon cancer xenografts.
Academic Article
Gemcitabine (2',2'-difluoro-2'-deoxycytidine), an antimetabolite that poisons topoisomerase I.
Academic Article
Mechanisms of action of FdUMP[10]: metabolite activation and thymidylate synthase inhibition.
Academic Article
Cooperative stabilization of Zn(2+):DNA complexes through netropsin binding in the minor groove of FdU-substituted DNA.
Academic Article
Unique dual targeting of thymidylate synthase and topoisomerase1 by FdUMP[10] results in high efficacy against AML and low toxicity.
Academic Article
Increased cytotoxicity and decreased in vivo toxicity of FdUMP[10] relative to 5-FU.
Academic Article
Positive interaction between 5-FU and FdUMP[10] in the inhibition of human colorectal tumor cell proliferation.
Academic Article
Antineoplastic activity of a novel multimeric gemcitabine-monophosphate prodrug against thyroid cancer cells in vitro.
Concept
Tumor Cells, Cultured
Academic Article
Selective anti-tumor activity of the novel fluoropyrimidine polymer F10 towards G48a orthotopic GBM tumors.
Search Criteria
Tumor Cells Cultured